Our model evaluates test materials for their potential to cause tissue damage by induction of fibrosis or for their potential anti-fibrotic activity.
Analysis is based upon fibroblast/myofibroblast conversion by cell population analysis, direct measurement of extracellular matrix deposition or upregulation of key genes involved in fibrosis pathogenesis.
Models of renal, lung and dermal fibrosis available.
Read our Technology Overview for more information.
Human Primary Renal Fibroblasts
Screening for inflammatory impact or anti-inflammatory potential. Analytical readouts: reactive oxygen species or pro-inflammatory cytokines.
Medium throughput system using human CD14+ monocyte, macrophage and/or dendritic cells.
Single cytokine or multiplexed cytokine bead-based analysis available.
Processes for the evaluation of nanosafety in development.
Evaluates therapeutic potential in the treatment of cancer using conventional 2D models or 3D models with enhanced predictive value.
Analytical readouts ranging from simple indices of cell health to cancer-relevant molecular targets using cell marker or PCR-based gene expression to microarray-based gene expression profiling.
A range of primary cancer cells available for application in screening assays.
Human Primary Mammary Tumour Cells
Diabetes (Type II)
Evaluates candidate therapeutic potential in terms of insulin sensitization of peripheral tissues using insulin-sensitive peripheral cells; human primary adipocytes (from pre-adipocyte precursors).
Measures glucose uptake as intracellular accumulation of fluorescent non-metabolised glucose analogue.
Human Differentiated Adipocytes
Lung Epithelial Barrier Models
Air-liquid-interface barrier model incorporating human primary upper or lower airway cells.
Effective in the evaluation of lung disease therapeutics.
Healthy and diseased cell options available.
Human Primary Bronchial Tree Epithelial Cells
Custom Cell Isolation
Available upon request for non-standard cell types or collections with specific requirements. Custom products include;
- Rare or specific cell types
- Additional testing e.g. CMV/EBV status
Customer Testimonial (1)
“We have done many projects with AvantiCell. Based on this, I can attest to their high level of science and high quality, trustworthy data. Communication is excellent and projects are completed within the agreed timelines. Highly recommended!”
Ruairí Mac Síomóin,
Eolas Biosciences Co. Ltd.
Customer Testimonial (2)
"Having worked with AvantiCell Science for many years, we have enjoyed a very successful business relationship. They always demonstrate flexibility in the services they can provide alongside a professional and scientific approach. The team are friendly and responsive, and have a wealth of scientific expertise to bring to our projects."
A Biotechnology Company