AvantiCell specialises in the screening of traditional medicines and natural products. The Company has a proven track record in identifying and characterising bioactivities with therapeutic potential in materials as diverse as tropical plant extracts, marine microbial cultures and Traditional Chinese Medicines.

AvantiCell's specialised systems have proven application in:

• Cell-biological validation of established traditional
• therapeutics

• Discovery of novel therapeutics from natural sources

• De-construction of natural product bioactivities for
• development of synthetic analogues

• Bioactivity monitoring during commercial bioactive
• production from natural sources, for process
• development and quality control purposes

Assay systems have been adapted through extensive research and development to accommodate the complex mixtures of biochemical molecules found in natural materials. Service delivery is based on a series of sample evaluation processes which enable critical analysis of cell-based screening data and distinction between on-target versus off-target non-specifc effects. These include:

• Sample presentation optimisation

• Pre-screening for autofluorescence

• Pre-screening for biochemical assay interference

• Cell-based assay conducted under conditions defined
• by autofluorescence and biochemical assay
• interference

• Post-screening titration of positive 'hit' bioactivities

Customers may select from one or more of these options.

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