AvantiCell's portfolio of Lead Development Assays add value to candidate therapeutics initially identified by high-throughput screening. These assays are generally not amenable to high-throughput and are made available as an in-house service for the testing of non-standard cell-parameters. Examples of in-house capability, which are adaptable to meet customer requirements, are:

• 3-D cytotoxicity assays for comprehensive safety
• testing
• Proteome Profiler assays for bioactivity elucidation
• Cell-transport assays for uptake / excretion study

AvantiCell 3-D Cytotoxicity Assays

AvantiCell will, during late 2009, launch unique cell-based assays utilising 3-D culture technology to enhance assay performance. cells cultured in 3-dimensons reproduce more faithfully their behavior in vivo compared with 2-D cell cultures and, importantly, respond to drugs and other test materials in a manner more preductive of these agents' effects in animal models or clinical tests. AvantiCell's 3-D cytotoxicity assays are, therefore, more likely to predict lead compound safety / toxicity in vivo. Please contact AvantiCell to discuss your 3-D culture requirements.

Proteome Profiling

Lead compound mechanism of action is examined in standard assay cell platforms by Proteome Profiler, a unique service which matches changes in test compound bioactivity with pre-determined cell-proteome profiles elicited by agents with known cellular mechanisms of action. Target-adapted assay services are individually priced according to cell-type, molecular target and sample provenance. Please contact AvantiCell to discuss your specific requirements.

AvantiCell Transport Assays

AvantiCell has adapted primary cell culture technology to facilitate the study of uptake, secretion or trans-cellular transport of test compounds including xenobiotics. Examples of cellular transport systems include:

• Primary bovine mammary cell monolayers, cultured
• on permeable membranes for study of trans-cellular
• transport into milk of environmental agents ingested
• by dairy animals
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• Human mammary epithelial cell W3.006 in monolayer
• cultures on permeable membranes for study of trans-
• cellular transport into human breast-milk of drugs,
• nutraceuticals or dairy compenents ingested by the
• breast-feeding mother

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